In this document, we, Karolinska Institutet, Department of Oncology-Pathology, Nordlund lab, invite vendors to submit offers for one state-of-the-art High Throughput High Resolution Mass Spectrometer System for isobaric tag Labelled Shotgun Proteomics applications, which remains the most widely used mode of analysis for discovery proteomics. We conduct IMPRINTS-CETSA analysis to elucidate cellular mechanism under cancer drug treatment, including studies of protein interaction changes and peptide regional cleavage, which require a parallel comparison of multiple biological replicates and a range of different treatments in an isobaric labeling format to give optimal data quality. To feasibly tackle the parallel and high-multiplexing proteomics analysis of many different samples, a high frequency of mass spectrum acquisition is crucial. The other critical capability of the required Mass Spectrometer is high resolution at the 120 to 140 m/z mass range so as to viably execute maximum isobaric labeling such as TMT32plex isobaric tag labelled analysis, giving superior quantitative interpretation, eventually aiming to reveal the key biological protein pathways behind cancer drug mechanism of action. The procurement includes delivery, installation of System/instruments with associated computer control and analysis software, extended equipment warranty, as well as training of personnel. Due to budget limitation the procurement includes the option of a factory refurbished instrument.
Sista ansökningsdag
Tidsfristen för mottagande av anbud var 2025-02-18.
Upphandlingen offentliggjordes den 2025-01-16.
Meddelande om upphandling (2025-01-16) Objekt Upphandlingens omfattning
Titel: A high resolution, high speed mass-spectrometry (MS) instrument,
Referensnummer: 2-52/2025
Kort beskrivning:
“In this document, we, Karolinska Institutet, Department of Oncology-Pathology, Nordlund lab, invite vendors to submit offers for one state-of-the-art High...”
Kort beskrivning
In this document, we, Karolinska Institutet, Department of Oncology-Pathology, Nordlund lab, invite vendors to submit offers for one state-of-the-art High Throughput High Resolution Mass Spectrometer System for isobaric tag Labelled Shotgun Proteomics applications, which remains the most widely used mode of analysis for discovery proteomics.
We conduct IMPRINTS-CETSA analysis to elucidate cellular mechanism under cancer drug treatment, including studies of protein interaction changes and peptide regional cleavage, which require a parallel comparison of multiple biological replicates and a range of different treatments in an isobaric labeling format to give optimal data quality. To feasibly tackle the parallel and high-multiplexing proteomics analysis of many different samples, a high frequency of mass spectrum acquisition is crucial. The other critical capability of the required Mass Spectrometer is high resolution at the 120 to 140 m/z mass range so as to viably execute maximum isobaric labeling such as TMT32plex isobaric tag labelled analysis, giving superior quantitative interpretation, eventually aiming to reveal the key biological protein pathways behind cancer drug mechanism of action.
The procurement includes delivery, installation of System/instruments with associated computer control and analysis software, extended equipment warranty, as well as training of personnel.
Due to budget limitation the procurement includes the option of a factory refurbished instrument.
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Beskrivning av upphandlingen:
“Karolinska Institutet, hereinafter called KI, invites companies, hereinafter called Tenderers, to submit tenders concerning a High Resolution high speed...”
Beskrivning av upphandlingen
Karolinska Institutet, hereinafter called KI, invites companies, hereinafter called Tenderers, to submit tenders concerning a High Resolution high speed Mass Spectrometer (MS) instrument.
The contract will be used by the Department of Oncology and Pathology, Bioclinicum.
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Plats för genomförandet: Stockholms län🏙️ Varaktighet
Startdatum: 2025-03-01 📅
Slutdatum: 2026-02-28 📅
Information om elektroniska kataloger
Anbuden skall presenteras i form av elektroniska kataloger eller innehålla en elektronisk katalog
Titel
Partiets identifikationsnummer: LOT-0001
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Beskrivning av upphandlingen:
“The Department of Oncology-Pathology, Nordlund lab, Karolinska Institutet (KI), Solna, will acquire a High Throughput High Resolution Mass Spectrometer...”
Beskrivning av upphandlingen
The Department of Oncology-Pathology, Nordlund lab, Karolinska Institutet (KI), Solna, will acquire a High Throughput High Resolution Mass Spectrometer System ("System").
We invite vendors to submit offers for one state-of-the-art High Throughput High Resolution Mass
Spectrometer System for isobaric tag labelled shotgun proteomics applications.
The two key capabilities are high resolution (specifically at the mass range 120 to 140 m/z) and high throughput. This specific mass range is needed for isobaric tag TMT32plex analysis, where reporter ion peaks (some of them with a mass difference of only 0.003 m/z between them) must be resolved so as to enable quantification. Under the desired resolution, a high acquisition rate is required to enable high throughput sample analysis.
The offered Mass Spectrometer should also be compatible with Ultimate 3000 HPLC (model: NCS-35000RS), which is already available in the lab.
Visa mer Titel
Partiets identifikationsnummer: LOT-0002
Förfarande Typ av förfarande
Öppet förfarande ✅ Administrativ information
Tidsfrist för mottagande av anbud eller begäran om deltagande: 2025-02-18 22:59:59 📅
Villkor för öppnande av anbud: 2025-02-18 23:00:00 📅
Villkor för öppnande av anbud (plats): Solna
Språk på vilka anbud eller ansökningar om deltagande kan lämnas in: svenska 🗣️
Minimitid under vilken anbudsgivaren måste upprätthålla anbudet: 98
Juridisk, ekonomisk, finansiell och teknisk information Villkor för deltagande
Förteckning och kortfattad beskrivning av regler och kriterier:
“Tender Suitability: The Tenderer fulfills all requirements in section 4. - Tender suitability.”
Kompletterande information Granskningsorgan
Namn: Förvaltningsrätten
Nationellt registreringsnummer: 202100-2742
Postnummer: 115 76
Postort: Stockholm
Region: Stockholms län🏙️
Land: Sverige 🇸🇪
E-post: forvaltningsrattenistockholm@dom.se📧
Telefon: 08-561 680 00📞
URL: https://www.domstol.se/forvaltningsratten-i-stockholm/🌏 Information om elektroniska arbetsflöden
Elektronisk fakturering kommer att accepteras
Elektronisk beställning kommer att användas
Elektronisk betalning kommer att användas
Källa: OJS 2025/S 012-034324 (2025-01-16)
Meddelande om upphandling (2025-02-14) Objekt Upphandlingens omfattning
Beräknat värde exklusive moms: 3 500 000 SEK 💰
Förfarande Administrativ information
Tidsfrist för mottagande av anbud eller begäran om deltagande: 2025-02-20 22:59:59 📅
Villkor för öppnande av anbud: 2025-02-20 23:00:00 📅
Kompletterande information En tjänst där information om omprövningsförfarandet kan erhållas
Namn: Förvaltningsrätten
Nationellt registreringsnummer: 202100-2742
Postnummer: 115 76
Postort: Stockholm
Region: Stockholms län🏙️
Land: Sverige 🇸🇪
E-post: forvaltningsrattenistockholm@dom.se📧
Telefon: 08-561 680 00📞
URL: https://www.domstol.se/forvaltningsratten-i-stockholm/🌏 Förfarande för översyn
Exakt information om tidsfrister för omprövningsförfaranden:
“tba”
Källa: OJS 2025/S 034-107184 (2025-02-14)