Beskrivning av upphandlingen
An advanced cell sorting instrument that can isolate up to four different cell populations with very high purity and viability in one and the same run.
The procurement.
The university of Gothenburg intends to procure a cell sorter instrument.
The instrument will mainly be used to identify immunological mechanisms involved in the beneficial effects of the female sex hormone estrogen in rheumatoid arthritis and associated osteoporosis.
To achieve this goal, it is important to be able to isolate involved cell populations with high purity and specificity, e.g. immune cells, stromal cells, osteoclasts and osteoblasts from primary and secondary lymphoid organs, to study how the function of these cell types is affected by estrogen. An advanced cell sorting instrument that can isolate up to four different cell populations with very high purity and viability in one and the same run needs to be purchased in order to study the sorted cell populations further in cell cultures or with multi-omic techniques where the cells' expression of genes, RNA, protein or metabolism is identified. This instrument will allow the user to map how the functions of the individual cell populations are affected by estrogen in their unique animal models, and thus be able to define immunological mechanisms involved in the protective effect of estrogen in arthritis and inflammation-induced osteoporosis.
The instrument will mainly be used by Ulrika Islanders research group, but also by other research groups at the Institute of medicine, University of Gothenburg, in order to fully use the instrument.